The antiviral activity of Egyptian Magnolia grandiflora on Human Immunodeficiency Virus (HIV)

MOHAMED SHAHEEN, SAMY MOSTAFA

Abstract


 

Objective:  This study was aimed to evaluate the in vitro antiviral activity of two extracts, methanol and aqueous, from the leaves of Magnolia grandiflora against the human immunodeficiency virus (HIV).

Methods: The cytotoxic and antiviral assays were performed by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) reduction colorimetric assay and TZM-bl reporter cell line, respectively.

Results: Our results suggested that both the extracts showed antiviral activity against HIV infection by interfering with the HIV life cycle in infected cells. The methanolic extract showed higher antiviral activity than the aqueous extract with SI= 2.74 and 1.84, respectively.

Conclusions: Our results demonstrate that in vitro infection with HIV can be effectively treated by methanol and aqueous extracts of Magnolia grandiflora leaves.

 


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